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Lambda Digest DNA

Force measurement of a single tethered Lambda-digest DNA molecule. During the extension of the molecule (red trace), the DNA first goes through the B-S transition (the plateau), and then melts to single-stranded DNA (ssDNA) at a higher force. During relaxation (purple trace), the DNA doesn't always re-anneal so the B-S transisition isn't always present.

Sample courtesy of H. Claussen-Schaumann and R. Krautbauer, Gaub Lab, Ludwig Maximilians University.